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kojic acid can inhibit the synthesis of tyrosinase, so it can strongly inhibit the formation of skin melanin, and it is safe, non-toxic, and will not produce leukoplakia sequelae kojic acid has been mixed into cosmetics, facial mask, lotion, and skin creams to make high-grade skin care cosmetics that can effectively treat freckles, liver spot, pigmentation, acne, etc. kojic acid with a concentration of 20ug/ml can inhibit the activity of a variety of tyrosinase (or polyphenol oxidase ppo) by 70-80%, and the amount of kojic acid added in cosmetics is generally 0.5-2.0%.syi