Daflon Full Prescribing Information Tablets, 500mg, 30 Tablets

Daflon 500 (500 Mg 60 Coated Tablets) Domino Hesperidin CHRONIC VENOUS DISEASE Around 60% of the adult population worldwide suffers from Chronic Venous Disease (EVC). Under normal conditions, the veins lead the blood back to the heart from the legs. For this they use valves that facilitate the flow of blood in the opposite direction to the force of gravity. Venous insufficiency (IV) is a condition in which the veins in your legs have difficulty returning blood to your heart. This pathology affects the valves of your veins whose main function is to prevent venous reflux. Problems with these valves cause a slowing of the venous return flow that causes blood to accumulate pathologically in the veins of the legs. WHAT IS DAFLON 500? Daflon 500 is indicated for the treatment of symptoms related to mild venous insufficiency in adults. Relieves, in adults, the symptoms of mild venous insufficiency of the legs, such as: pain, feeling of heaviness, tightness, tingling and itching in the legs with varicose veins and swollen legs. Daflon 500 has unique characteristics that have allowed us to gain the trust and loyalty of our doctors and patients over the years. TREATMENT The usual therapeutic dose is 2 tablets per day, divided into two doses, one tablet at noon and one at night, with meals. WHY DAFLON 500?Daflon 500 mg is the reference treatment, the most recommended and most prescribed, acting on all the symptoms of CVD (pain, heaviness of legs, tired legs and enema), thanks to the following factors: It has an exclusive composition, with proven synergistic efficacy of its purified micronized flavonoid fraction (FFPM). Its patented micronization reduces the particle diameter from 36.5 &micro's to 1.7 &micro's, which favours the absorption of the drug. Daflon 500 improves venous dispensability from the first hour. It can prevent the evolution of the disease and generates greater improvement of the symptoms as the treatment progresses. Daflon 500 is the most effective option to treat enema. Protects alular function and inhibits venous inflammation. Daflon 500 is the only effective medication in all the factors involved in the origin and evolution of chronic venous disease: venous tone, venous wall, capillary exudate, lymphatic drainage, haemorrhagic alterations and inflammation and microcirculation. ACTION AND MECHANISM Daflon 500 is a venotonic and vasoprotector. It produces vasoconstriction, increased resistance of the vessels and decreased permeability In the animal, it exerts a double action on the venous return system: at the level of veins and venues: it increases parietal tonicity and exerts an antistatic action; at the level of microcirculation: normalizes capillary permeability and strengthens capillary resistance. In man, double-blind controlled studies have confirmed venotonic activity: venous tone increases: plethysmography of venous occlusion with a mercury ring has revealed a decrease in venous emptying times. It has also shown activity on microcirculation: in patients who show signs of capillary fragility, capillary resistance measured by angio-sterometry increases. PHARMACKINETICS The pharmacokinetics of disomic (dappling) is linear.Orally:Absorption: Daflon 500 is rapidly transformed by the intestinal flora and is absorbed in its aglycone form (diosmosing). Bioavailability: 57.9% approx. Distribution: extensive (Veda: 62.1 L). Metabolism: Diosmosing degrades rapidly and widely to phlebotomy acids or their derivatives conjugated with glycine, which are eliminated in the urine. Predominant metabolite: hydroxyphenylpropionic acid (which is mostly eliminated in conjugate). Metabolites in smaller amounts: other phenolic acids corresponding to 1-hydroxy-4-methoxybenzoic acid, 3-methoxy-4-hydroxyphenylacetic acid and 3, 4-dihydroxybenzoic acid. Elimination: relatively fast. In studies with radioactively labelled disomic, 34% of the dose was recovered in urine and faces after the first 24 hours, and approximately 86% recovered in urine and faces after the first 48 hours.